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Some Drugs Make Dementia Worse — ElderConsult. Aspirin-acetaminophen oral and prednisone oral Drug.. Can you take prednisone and tylenol Compare generic prednisone 40 mg erectile dysfunction one. Apo-Prednisone Prednisone belongs to the group of medications called corticosteroids. It is used to treat a number of conditions. It is more commonly used to. Prednisone is quite tough on the digestive system though, so you should look to take it with some crackers or something so it doesn't mess with your stomach too much but the tylenol is safe to take while taking prednisone Take care.