Viagra invented

Discussion in 'Prescription Drug Cost' started by Avva, 18-Aug-2019.

  1. Entrepreneur Guest

    Viagra invented


    Viagra (sildenafil) is one of the most widely-known prescription drug names on the U. ED is a common sexual problem for men and its frequency increases with age. Pfizer realized ED was an unmet medical need and a major opportunity for financial gain. Often dubbed "the little blue pill", Viagra (sildenafil) was the first phosphodiesterase 5 (PDE5) inhibitor approved to treat erectile dysfunction (ED). During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina. The sildenafil compound was originally developed by Pfizer for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain due to heart disease). The discovery that sildenafil could lead to an erection was an unplanned event. survey determined about 50 percent of men 40 to 70 years of age experience some degree of ED. In 1998, the FDA approved Viagra, the first oral treatment for erectile dysfunction, under a priority review. At the time of its approval, Viagra had the fastest initial sales growth following its launch of any prescription product, reaching 2008 sales of close to $2 billion. Mary Bellis, known by some as Calm X, was an experimental artist, film director and producer, video game content creator, and freelance writer for some 18 years. She specialized in writing about inventors and inventions, in particular. According to the British Press, Peter Dunn and Albert Wood are named as the inventors of the process by which Viagra was created. Their names appeared on an application by Pfizer to patent (WOWO9849166A1) the manufacturing process of Sildenafil Citrate, better known as Viagra. Peter Dunn and Albert Wood are both employees of Pfizer Pharmaceuticals at the Pfizer run research laboratories in Kent and thus are not allowed to discuss their status or non-status as inventors. In a statement Albert Wood said: "I can't say anything, you'll have to talk to the press office..." "Life might seem cruel, but they are paid to work for the company and the company owns their inventions. Literally hundreds of people at Pfizer have been involved in developing the drug. Nicholas Terrett discovered that chemical compounds belonging to the pyrazolopyrimidinone class were useful in treating heart problems such as angina. You can't really point to two individuals and say they spawned Viagra." Anyhow, to the best of our knowledge, this is how the story goes. Some experts consider Terrett as the father of Viagra as he was named in the 1991 British patent for Sildenafil (tradenamed Viagra) as a possible heart medicine.

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    Dec 11, 2017. The story of the drug that changed sex and made billions. Approved 19 years ago, Pfizer Inc.'s Viagra ushered in a pharmaceutical and. Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Sunstance sildenafil Viagra was invented almost the same way. In the early nineties, in the UK pharmacologists were working on a new drug for the treatment of.

    To bring you the best content on our sites and applications, Meredith partners with third party advertisers to serve digital ads, including personalized digital ads. Those advertisers use tracking technologies to collect information about your activity on our sites and applications and across the Internet and your other apps and devices. You always have the choice to experience our sites without personalized advertising based on your web browsing activity by visiting the DAA’s Consumer Choice page, the NAI's website, and/or the EU online choices page, from each of your browsers or devices. To avoid personalized advertising based on your mobile app activity, you can install the DAA’s App Choices app here. You can find much more information about your privacy choices in our privacy policy. Even if you choose not to have your activity tracked by third parties for advertising services, you will still see non-personalized ads on our site. It’s not a secret that some scientific discoveries that have greatly changed the picture of the world, were made by accident. Taking the bath, the scientist from ancient Greece called Archimedes discovered the hydrostatic law, which is used by the experts in shipbuilding. Mendeleev had seen some of his world-famous discoveries in his dreams. It turns out that simple accidents promoted the advancement of science. Scientists decided to create the drug for the treatment of the numerous heart diseases. It turned out that they have been implicated in one of the greatest discoveries in the world of pharmacy. It all started when in Great Britain (the small city of Pfizer) the scientists started the research with the use of active substance called Sildenafil citrate. It was meant to help the people with heart diseases by increasing the blood flow to the myocardium.

    Viagra invented

    Hugely Successful Products Originally Invented for Something., Sildenafil - Wikipedia

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  4. Though unconfirmed, it is believed the drug was invented by Peter Dunn and Albert Wood. https//.

    • FDA approves Viagra - HISTORY.
    • The history of creation of Viagra. Viagra Information Website..
    • Robert Furchgott Paved the Way for Viagra Blog.

    When the FDA approved Viagra on March 27, 1998, it was offering a. federal regulators approved Viagra — the little blue pill that made it a. Viagra's discovery. Even the fastest selling drug of all time, Viagra, is not used for what it was originally intended. It started life as plain old UK92480, a new treatment for angina, a heart condition that constricts the vessels that supply the heart with blood. Sep 25, 2018. Pfizer called it Viagra and made tens of billions of dollars over the next. I first got my hands on some Viagra for a writing assignment in 2002.

     
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    Prophylaxis 80 mg/day PO divided q6-8hr initially; may be increased by 20-40 mg/day every 3-4 weeks; not to exceed 160-240 mg/day divided q6-8hr Inderal LA: 80 mg/day PO; maintenance: 160-240 mg/day Withdraw therapy if satisfactory response not seen after 6 weeks Hemangeol: Indicated for treatment of proliferating hemangioma requiring systemic therapy Initiate treatment at aged 5 weeks to 5 months Starting dose: 0.6 mg/kg (0.15 m L/kg) PO BID for 1 week, THEN increase dose to 1.1 mg/kg (0.3 m L/kg) BID; after 2 more weeks, increase to maintenance dose of 1.7 mg/kg (0.4 m L/kg) BID PO: 0.5-1 mg/kg/day divided q6-8hr; may be increased every 3-7 days; usual range: 2-6 mg/kg/day; not to exceed 16 mg/kg/day or 60 mg/day IV: 0.01-0.1 mg/kg over 10 minutes; repeat q6-8hr PRN; not to exceed 1 mg for infants or 3 mg for children PO: 1 mg/kg/day divided q6hr; after 1 week, may be increased by 1 mg/kg/day to maximum of 10-15 mg/kg/day if patient refractory; allow 24 hours between dosing changes IV: 0.01-0.2 mg/kg over 10 minutes; not to exceed 5 mg Immediate-release: 40 mg PO q12hr initially, increased every 3-7 days; maintenance: 80-240 mg PO q8-12hr; not to exceed 640 mg/day Inderal LA: 80 mg/day PO initially; maintenance: 120-160 mg/day; not to exceed 640 mg/day Inno Pran XL: 80 mg/day PO initially; may be increased every 2-3 weeks until response achieved; maintenance: not to exceed 120 mg/day PO Consider lower initial dose PO: 10 mg q6-8hr; may be increased every 3-7 days IV: 1-3 mg at 1 mg/min initially; repeat q2-5min to total of 5 mg Once response or maximum dose achieved, do not give additional dose for at least 4 hours Aggravated congestive heart failure Bradycardia Hypotension Arthropathy Raynaud phenomenon Hyper/hypoglycemia Depression Fatigue Insomnia Paresthesia Psychotic disorder Pruritus Nausea Vomiting Hyperlipidemia Hyperkalemia Cramping Bronchospasm Dyspnea Pulmonary edema Respiratory distress Wheezing Allergic: Hypersensitivity reactions, including anaphylactic/anaphylactoid; agranulocytosis, erythematous rash, fever with sore throat Skin: Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, urticaria Musculoskeletal: Myopathy, myotonia May exacerbate ischemic heart disease after abrupt withdrawal Hypersensitivity to catecholamines has been observed during withdrawal Exacerbation of angina and, in some cases, myocardial infarction occurrence after abrupt discontinuance When discontinuing long-term administration of beta blockers (particularly with ischemic heart disease), gradually reduce dose over 1-2 weeks and carefully monitor If angina markedly worsens or acute coronary insufficiency develops, reinstate beta-blocker administration promptly, at least temporarily (in addition to other measures appropriate for unstable angina) Warn patients against interruption or discontinuance of beta-blocker therapy without physician advice Because coronary artery disease is common and may be unrecognized, slowly discontinue beta-blocker therapy, even in patients treated only for hypertension Asthma, COPD Severe sinus bradycardia or 2°/3° heart block (except in patients with functioning artificial pacemaker) Cardiogenic shock Uncompensated congestive heart failure Hypersensitivity Overt heart failure Sick sinus syndrome without permanent pacemaker Do not use Inno Pran XL in pediatric patients Long-term beta blocker therapy should not be routinely discontinued before major surgery; however, the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures Use caution in bronchospastic disease, cerebrovascular insufficiency, congestive heart failure, diabetes mellitus, hyperthyroidism/thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease, myasthenic conditions Sudden discontinuance can exacerbate angina and lead to myocardial infarction Use in pheochromocytoma Increased risk of stroke after surgery Hypersensitivity reactions, including anaphylactic and anaphylactoid reactions, have been reported Cutaneous reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, and urticaria, have been reported Exacerbation of myopathy and myotonia has been reported Less effective than thiazide diuretics in black and geriatric patients May worsen bradycardia or hypotension; monitor HR and BP Avoid beta blockers without alpha1-adrenergic receptor blocking activity in patients with prinzmetal variant angina; unopposed alpha-1 adrenergic receptors may worsen anginal symptoms May induce or exacerbate psoriasis; cause and effect not established Prevents the response of endogenous catecholamines to correct hypoglycemia and masks the adrenergic warning signs of hypoglycemia, particularly tachycardia, palpitations, and sweating May cause or worsen bradycardia or hypotension Pregnancy category: C; intrauterine growth retardation, small placentas, and congenital abnormalities reported, but no adequate and well-controlled studies conducted Lactation: Use is controversial; an insignificant amount is excreted in breast milk Nonselective beta adrenergic receptor blocker; competitive beta1 and beta2 receptor inhibition results in decreases in heart rate, myocardial contractility, myocardial oxygen demand, and blood pressure Class 2 antidysrhythmic Bioavailability: 30-70% (food increases bioavailability) Onset: Hypertension, 2-3 wk; beta blockade, 2-10 min (IV) or 1-2 hr (PO) Duration: 6-12 hr (immediate release); 24-27 hr (extended release) Peak plasma time: 1-4 hr (immediate release); 6-14 hr (extended release) Solution: Most common solvents Additive: Dobutamine, verapamil Syringe: Inamrinone, milrinone Y-site: Alteplase, fenoldopam, gatifloxacin, heparin, hydrocortisone, sodium succinate, inamrinone, linezolid, meperidine, milrinone, morphine, potassium chloride, propofol, tacrolimus, tirofiban, vitamins B and C IV administration rate should not exceed 1 mg/min IV dose is much smaller than oral dose Give by direct injection into large vessel or into tubing of free-flowing compatible IV solution Continuous IV infusion generally is not recommended The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Inderal Oral Uses, Side Effects, Interactions, Pictures, Warnings. Propranolol Oral Route Side Effects - Mayo Clinic Beta-Blockers
     
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    Sildenafil Oral Uses, Side Effects, Interactions, Pictures, Warnings. Find patient medical information for Sildenafil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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