Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international team of scientists led by researchers at the National Institute on Aging (NIA), part of the National Institutes Health. The study, which tested two doses of the drug in the male mice, found the higher dose to be toxic in the animals. Scientists emphasized that considerably more research is needed before the implications of metformin for healthy aging are known for humans. D., of the NIA’s Intramural Research Program, was published in the July 30, 2013 issue of Nature Communications. “It is exciting to discover that a drug already known to be safe and effective in humans might be further studied for a possible, alternate use for healthy aging.” Prescribed since the 1960s to treat type 2 diabetes, metformin is known to enhance insulin sensitivity, prompt sugar to be converted to energy, and prevent sugar build up in the liver. “There is increasing interest in exploring how drugs for one use might be repurposed for another,” notes Richard J. It also reduces risk of health issues associated with metabolic syndrome, a condition characterized by an increased chance for heart disease and stroke, as well as type 2 diabetes. “Aging is a driving force behind metabolic syndrome and diabetes. Given that metformin is clinically proven to alleviate symptoms of these conditions, and reduce risk of cancer, we thought perhaps it was a good candidate to study for its broader effects on health and lifespan,” said de Cabo. Specifically, de Cabo’s research focuses on testing compounds that might mimic benefits of calorie restriction, as shown in some animal models. Some exciting research from the University of Montreal has found that the drug metformin, commonly prescribed for diabetes and polycystic ovary syndrome (PCOS), has the potential to slow aging and fight cancer. The study, published in , found that metformin reduces the body's production of inflammatory cytokines, which accelerate aging. Metformin is the generic name for an oral drug that was approved by the FDA in 1994 to lower blood sugar. Brand names include Glucophage and Glucophage XR (Bristol-Myers Squibb), Fortamet (Shionogi), Glumetza and Glumetza XR (Santarus), and Riomet (Ranbaxy). Metformin was later found to stimulate ovulation, regulate periods, and increase fertility in women with PCOS and is now commonly prescribed for women whose PCOS hasn't responded to hormonal treatment alone. Found: New Potential to Slow Aging, and Slow Tumor Growth Cytokines have an important function in the body, activating the immune system to fight infection. But because they work by an inflammatory process, when they're overproduced they put the body into a state of chronic inflammation, which causes cells to age faster. Buy viagra online with paypal in canada Were can i buy valtrex Amoxicillin dogs Prednisone and alcohol The more researchers learn about metformin, the more it seems like a medieval wonder drug that could boost longevity in the 21st century. Metformin Targets Multiple Pathways of Aging The ﬁgure depicts schematically the current consensus within the biology of aging community as to pathways that are important in order to target aging and indicates at which points metformin has been shown to have effects see text. Key take-away outside of the cell 1, top, metformin has been. Metformin, a generic drug that's used to treat Type 2 diabetes, could help people live longer, healthier lives. Watch the TEDMED talk by AFAR Deputy Scientific Director Nir Barzilai, Can We Grow Older Without Getting Sicker? The entire National Geographic special, Breakthrough: The Age of Aging, spotlighting TAME and featuring AFAR experts, can be purchased on i Tunes or Amazon. Years ago I was excited about the thought of metformin being part of anti aging protocol. The latest research that I have read shows that metformin could increase chance of dementia in healthy older adults. Reply I take some supplements for their anti-aging benefits, but I would not take metformin, at least not until a lot more study is done on its benefits/drawbacks for healthy people (and those studies are not likely to be done anytime soon, as John says). I had a little test drive with metformin, took 1000mg and increased to 2000mg a day for almost 3 weeks. There are studies out there that found that Vitamin B12 deficiency is very common among metformin users, which is disturbing: https://gov/pubmed/21940283 Lots of other potential negative side effects also. My appetite went down, it felt like my stomach was fuller after meals and that my digestion was slower kind of how you feel after a heavy meal. Energy was lower when walking around and in the gym, which coincides with the lower VO2 max. I’ve tried metformin too, might have made me less hungry. The fact that all these rats studies are made with the equivalent diet of very unhealthy people makes me look at most studies with more skepticism. But I’ve only taken 500 mg at a time, and not daily. From the study on exercise and metformin, seems like one might get some benefit from metformin by taking it only sporadically and not on exercise days. Metformin and aging Metformin and Its Anti-Aging Use, Metformin as a Tool to Target Aging - Diflucan liver damagePrednisone what isAmoxil dosage for dogs Metformin, The Anti-Aging Miracle Drug. Diabetes Drugs Take A BAD RAP. by Jeffrey Dach MD. This article is part two of a series, for part one, click here. You probably think of Diabetes Drugs as all lumped together as “Bad Drugs”. Metformin The Anti-Aging Miracle Drug - Jeffrey Dach MD. Cheap, generic metformin could be the next anti-aging drug -.. NIH researchers find diabetes drug extends health and lifespan in.. Metformin Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists AHFS DI. The anti-diabetic drug metformin is widely touted as a drug that fights aging, which would be great if true. Metformin Hydrochloride Tablets USP are oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin hydrochloride N,N-dimethylimidodicarbonimidic diamide hydrochloride is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents.