Metformin and aging

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  1. Snorry Guest

    Metformin and aging


    Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international team of scientists led by researchers at the National Institute on Aging (NIA), part of the National Institutes Health. The study, which tested two doses of the drug in the male mice, found the higher dose to be toxic in the animals. Scientists emphasized that considerably more research is needed before the implications of metformin for healthy aging are known for humans. D., of the NIA’s Intramural Research Program, was published in the July 30, 2013 issue of Nature Communications. “It is exciting to discover that a drug already known to be safe and effective in humans might be further studied for a possible, alternate use for healthy aging.” Prescribed since the 1960s to treat type 2 diabetes, metformin is known to enhance insulin sensitivity, prompt sugar to be converted to energy, and prevent sugar build up in the liver. “There is increasing interest in exploring how drugs for one use might be repurposed for another,” notes Richard J. It also reduces risk of health issues associated with metabolic syndrome, a condition characterized by an increased chance for heart disease and stroke, as well as type 2 diabetes. “Aging is a driving force behind metabolic syndrome and diabetes. Given that metformin is clinically proven to alleviate symptoms of these conditions, and reduce risk of cancer, we thought perhaps it was a good candidate to study for its broader effects on health and lifespan,” said de Cabo. Specifically, de Cabo’s research focuses on testing compounds that might mimic benefits of calorie restriction, as shown in some animal models. Some exciting research from the University of Montreal has found that the drug metformin, commonly prescribed for diabetes and polycystic ovary syndrome (PCOS), has the potential to slow aging and fight cancer. The study, published in , found that metformin reduces the body's production of inflammatory cytokines, which accelerate aging. Metformin is the generic name for an oral drug that was approved by the FDA in 1994 to lower blood sugar. Brand names include Glucophage and Glucophage XR (Bristol-Myers Squibb), Fortamet (Shionogi), Glumetza and Glumetza XR (Santarus), and Riomet (Ranbaxy). Metformin was later found to stimulate ovulation, regulate periods, and increase fertility in women with PCOS and is now commonly prescribed for women whose PCOS hasn't responded to hormonal treatment alone. Found: New Potential to Slow Aging, and Slow Tumor Growth Cytokines have an important function in the body, activating the immune system to fight infection. But because they work by an inflammatory process, when they're overproduced they put the body into a state of chronic inflammation, which causes cells to age faster.

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    Aging in humans is a well-established primary risk factor for many disabling diseases and conditions, among them diabetes, cardiovascular disease, Alzheimer's disease and cancer. Metformin Anti Aging - Worst Skin Care Products For 2016 Metformin Anti Aging Doctor Oz Wrinkle Creams Eye Wrinkles Worse With Retinol Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international.

    Watch the TEDMED talk by AFAR Deputy Scientific Director Nir Barzilai, Can We Grow Older Without Getting Sicker? The entire National Geographic special, Breakthrough: The Age of Aging, spotlighting TAME and featuring AFAR experts, can be purchased on i Tunes or Amazon. Years ago I was excited about the thought of metformin being part of anti aging protocol. The latest research that I have read shows that metformin could increase chance of dementia in healthy older adults. Reply I take some supplements for their anti-aging benefits, but I would not take metformin, at least not until a lot more study is done on its benefits/drawbacks for healthy people (and those studies are not likely to be done anytime soon, as John says). I had a little test drive with metformin, took 1000mg and increased to 2000mg a day for almost 3 weeks. There are studies out there that found that Vitamin B12 deficiency is very common among metformin users, which is disturbing: https://gov/pubmed/21940283 Lots of other potential negative side effects also. My appetite went down, it felt like my stomach was fuller after meals and that my digestion was slower kind of how you feel after a heavy meal. Energy was lower when walking around and in the gym, which coincides with the lower VO2 max. I’ve tried metformin too, might have made me less hungry. The fact that all these rats studies are made with the equivalent diet of very unhealthy people makes me look at most studies with more skepticism. But I’ve only taken 500 mg at a time, and not daily. From the study on exercise and metformin, seems like one might get some benefit from metformin by taking it only sporadically and not on exercise days.

    Metformin and aging

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  7. Metformin, The Anti-Aging Miracle Drug. Diabetes Drugs Take A BAD RAP. by Jeffrey Dach MD. This article is part two of a series, for part one, click here. You probably think of Diabetes Drugs as all lumped together as “Bad Drugs”.

    • Metformin The Anti-Aging Miracle Drug - Jeffrey Dach MD.
    • NIH researchers find diabetes drug extends health and lifespan in..
    • Metformin – Wikipedia.

    Metformin Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists AHFS DI. Metformin Hydrochloride Tablets USP are oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin hydrochloride N,N-dimethylimidodicarbonimidic diamide hydrochloride is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. An anti-aging powerhouse right under our noses? Metformin, a drug commonly prescribed for diabetes, may slow aging and cancer tumor growth, new research shows.

     
  8. fish Guest

    When it comes to ulcerative colitis, there are different options for treatment. The treatment your doctor prescribes for you often depends on the severity of your symptoms. Two drugs you may hear about are prednisone and prednisolone. (A third drug, methylprednisolone, is stronger than both and should not be confused with prednisolone.) Here’s the rundown on what these drugs are and how they can help treat ulcerative colitis, including how they’re alike and how they’re different. Prednisone and prednisolone both belong to a class of drugs called glucocorticoids. Glucocorticoids reduce inflammation throughout your body. They do this by interfering with the way certain chemicals in your body cause inflammation. These drugs can work in different parts of your body, including your colon. Your colon is the last section of your large intestine, just before your rectum. Prednisolone sodium phosphate - Wikipedia Methylprednisolone - Wikipedia TalkPrednisolone in Severe Alcoholic Hepatitis - Wiki Journal Club
     
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  10. grayscaler Guest

    Regular exams needed to detect ocular complications of cancer therapy David I. Kaufman, DO, who participated in a study of the ocular side effects of tamoxifen, noted that, with tamoxifen specifically, there is a potential for patients to.

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