Tamoxifen bone density

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  1. tanyatan Guest

    Tamoxifen bone density


    This happens gradually over time but is much more significant after the menopause. Around the age of 35 we start to lose bone density as part of the natural ageing process. Back to top Our bones increase in density and strength until we reach our late 20s. Although osteoporosis cannot be cured, treatments are available to try to keep the bones strong and less likely to fracture. The most common sites for a fracture to occur are the wrist, hip and back (spine). Generally, osteoporosis causes no pain or symptoms, so often a person won’t realise they have the condition until a fracture happens. These fractures are often described as ‘fragility fractures’. Treatments used for breast cancer can increase the risk of developing osteoporosis. This page discusses how this might happen and provides information on the effects of chemotherapy, Tamoxifen and Aromatase inhibitors on bone. There is also information on the benefits of diet and weight bearing exercise to help with bone strength if you also are being treated for breast cancer. Women who have had breast cancer may be at increased risk of developing osteoporosis: the loss of bone strength, making bones more fragile and prone to fracture. If you have been diagnosed with breast cancer, you should ask your doctor to check your bone health, especially if you have other risk factors for osteoporosis such as a family history, low calcium intake and/or low vitamin D levels. Two measures of bone health are important to consider: Women with breast cancer have an increased risk of developing osteoporosis because of the treatments used in breast cancer. Treatments can impact directly on oestrogen levels (vital for bone strength), and may also cause ovarian failure in premenopausal women, resulting in a further significant fall in oestrogen and a premature/early menopause.

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    In the women who received tamoxifen for the two years of the study, bone mineral density at the lumbar spine increased by 0.72 percent per year P = 0.01; in contrast, in the women who received. Med Oncol. 2004;212117-21. Effects of tamoxifen on bone mineral density and metabolism in postmenopausal women with early-stage breast cancer. We analyzed bone mineral density BMD in Sw. tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study SAKK 21/07.

    uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website. Your risk of osteoporosis (bone thinning) can be affected by breast cancer treatment and other treatments that lower your oestrogen levels. Osteoporosis is thinning of the bones so that they become more brittle. Our bones start to thin after the age of 35 or so, as part of the natural ageing process. Any cancer treatment in women that lowers oestrogen levels can increase the risk of osteoporosis. These treatments include: Tamoxifen for breast cancer usually only reduces bone density by a small amount. In postmenopausal women, aromatase inhibitors increase bone loss at an average rate of 1 to 3% per year. In young women who have had ovarian suppression followed by aromatase inhibitor therapy, bone density is lost at an average of 7 to 8% per year. Treatment with tamoxifen for 2 to 5 years before having aromatase inhibitors may slow down the rate of bone loss. Women who have had an early menopause (before the age of 45) due to cancer treatment or who have ovarian suppression therapy and aromatase inhibitors are at higher risk of bone loss.

    Tamoxifen bone density

    Breast cancer & bone health Jean Hailes, Effects of tamoxifen on bone mineral density and metabolism in.

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  4. All aromatase inhibitors can cause bone loss. Tamoxifen can be used to treat both pre and postmenopausal women. Tamoxifen lowers bone density only in.

    • Bone health and breast cancer - Breast Cancer Network Australia.
    • Bone mineral density in breast cancer patients treated with adjuvant..
    • Bone health and osteoporosis - Breast Cancer Care.

    Tamoxifen and bone density 59 found primarily in postmenopausal women have. 21/06/2018 find out about how hormone - certain cancer symposium. Correct response the risk and body adds new, hormonal imbalance. Nov 2, 2017. Because estrogen helps maintain bone density, this drop can lead to. For postmenopausal women, tamoxifen's effects on bone is similar to. Tamoxifen for breast cancer usually only reduces bone density by a small amount. In postmenopausal women, aromatase inhibitors increase bone loss at an average rate of 1 to 3% per year.

     
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