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    In part 1 - "TRT and Fertility – how to get the best of both worlds" - I covered issues related to the effect of TRT (Testosterone Replacement Therapy) on male fertility. Here I will outline options for men to increase endogenous testosterone production by non-TRT means, and ways to speed up spermatogenesis for those who chose to go the TRT route... Tirabassi, G., et al., Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism. A study induced experimental gonadotropin deficiency in 37 normal men with gonadotropin-releasing hormone (Gn RH) antagonists and randomized the men to receive one of four doses of h CG: 0, 15, 60, or 125 IU subcutanesouly every other day for 10 days.[1] Testicular fluid was obtained by percutaneous aspiration for steroid measurements at baseline and after 10 days of treatment. The ITT levels increased in a dose-dependent manner, with very low-dose h CG administration Moreover, blood levels of HCG were significantly correlated with both ITT and blood testosterone levels. Carruthers, M., The paradox dividing testosterone deficiency symptoms and androgen assays: a closer look at the cellular and molecular mechanisms of androgen action. It was concluded that doses of HCG that ware far lower than those typically used clinically (1,000–2,000 IU SC three times weekly) increased ITT concentrations in a dose-dependent manner in normal men with experimental gonadotropin deficiency.[1] To investigate how HCG affects the different fractions of serum T, eugonadal healthy men were injected with 6000 IU HCG i.m.[2] Blood was collected every 10 min for 2.5 h and then once a day for 4 days. By day 4 the mean serum testosterone level had risen to 178% /- 13% (SEM) of a mean basal level (first five samples). Crabbe, P., et al., Part of the interindividual variation in serum testosterone levels in healthy men reflects differences in androgen sensitivity and feedback set point: contribution of the androgen receptor polyglutamine tract polymorphism. This rise was less than that in free testosterone (221% /- 18%), which was in turn less than the rise in the non-SHBG-bound fraction (255% /- 19%). How to Take Clomid for Infertility - Verywell Family Alternative Treatment options for Low Testosterone Men's Health. Clomifene - Wikipedia
     
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