Tamoxifen in breast cancer

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  1. LanSib XenForo Moderator

    Tamoxifen in breast cancer


    In 2005, my mother was diagnosed with ovarian cancer and in 2006, my older sister faced a diagnosis of lobular breast cancer. Although both lived in Florida, I insisted they come to Houston to be treated at with my sister, I mentioned to her oncologist that I’d noticed an unusual discharge from my nipple. But based on my experiences and the specialized expertise of the radiologists, I decided to begin getting routine mammograms at . She advised me to make an appointment immediately to see Therese Bevers, M. When a world-class oncologist makes such a strong recommendation, I heed their advice. In 2012, my mammogram showed an area that necessitated a biopsy. Fortunately, the biopsy came back normal, but three years later, Dr. Bevers noted a suspicious area in the opposite breast. A second biopsy showed abnormal cellular changes, or atypical hyperplasia, but not cancer. At that point, I began to accept that I had an increased risk for breast cancer. Bevers had explained that my family and personal history placed me at a higher than average risk and discussed possibly starting a preventive therapy medication, such as tamoxifen, to reduce that risk. After all, I was in great health, led an active lifestyle, was at an ideal weight, ate a healthy diet and generally did all the right things to ensure that I would remain healthy for a long time. But they do know that some breast cancer cells are sensitive to estrogen. In order to fuel that growth, estrogen must attach itself to those breast cancer cells. Doctors think that tamoxifen stops estrogen from attaching to the cell. No estrogen means no growth for these types of breast cancer cells. Tamoxifen also keeps healthy breast cells from growing and multiplying. That way, it also reduces the number of cells that could become cancer. In a study of more than 13,000 women at high risk for breast cancer, scientists found that women who took tamoxifen for 5 years had fewer breast cancers than women who took a placebo. Newer research suggests that taking the drug for 10 years lowers the risk even more.

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    Jun 27, 2017. WebMD looks at the use of the drug tamoxifen for treating breast cancer and preventing it in high-risk cases. Jan 16, 2019. Tamoxifen is a common medication used to prevent recurrence of breast cancer. Learn about the side effects, risks, drug interactions, and. Dec 17, 2010. Tamoxifen was the first targeted anticancer agent for breast cancer patients and its effects on reduction of breast cancer events and.

    Tamoxifen and raloxifene have been shown to reduce the risk breast cancer, but they can have their own risks and side effects. Tamoxifen and raloxifene are the only drugs that are approved in the US to help lower the risk of breast cancer, although for some women, drugs called aromatase inhibitors might be an option as well. This means that they act against (or block) estrogen (a female hormone) in some tissues of the body, but act like estrogen in others. Estrogen can fuel the growth of breast cancer cells. Tamoxifen can be taken whether or not you have gone through menopause, but raloxifene is only approved for post-menopausal women. Both of these drugs block estrogen in breast cells, which is why they can be useful in lowering breast cancer risk. To lower the risk of breast cancer, these drugs are taken for 5 years. The effect of these drugs on breast cancer risk has varied in different studies. When the results of all the studies are taken together, the overall reduction in risk for these drugs is about 40% (more than a third). These drugs lower the risk of both invasive breast cancer and ductal carcinoma in situ (DCIS). Although a medicine that cuts your risk by about 40% sounds like it must be a good thing, what it would really mean for you depends on how high your risk is in the first place (your baseline risk). Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted.

    Tamoxifen in breast cancer

    Tamoxifen Breast Cancer Care, Tamoxifen for Reducing Breast Cancer Recurrence - Verywell Health

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  3. Oct 16, 2018. Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. Tamoxifen is approved by the.

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    Sep 6, 2017. For women at higher risk of breast cancer, drugs such as tamoxifen and raloxifene have been shown to help reduce the risk. Tamoxifen. Tamoxifen Nolvadex has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Find information about tamoxifen, a medicine to treat breast cancer, from Cleveland Clinic, including side effects, precautions, concerns, and more.

     
  4. Obram New Member

    The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I was on Cipro for a long time with all kinds of negative side effects and the infection just kept recurring. Went to a new doctor, Integrative Medicine, he told me to take d-mannose every morning & every, night one pill. The urinary tract infection cleared up quickly and the only time it got bad again is if I foolishly forget to take the d-mannose. Check it out""Dr prescribed 500 mg twice a day for 5 days. The UTI was horrible, but I’ve never experienced such horrible side effects from an antibiotic. I stuck with it because the UTI scared me, but after just taking the last dose, I’m still certain my UTI is lingering. Nausea was debilitating, I was fighting to keep from vomiting. Maybe I’m imagining this, but my thinking and moods seem to have been dark. Within 3-4 hours after taking only one pill the urgency and burning sensations are reduced to a bearable level. Extended-release ciprofloxacin Cipro XR for treatment of urinary tract. How long for cipro to work on uti Bienvenida Contenidos CIPRO XR ciprofloxacin hydrochloride - FDA
     
  5. Tolum XenForo Moderator

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