Generic Name: Misoprostol Class: Prostaglandins - Antiulcer Agents ATC Class: A02BB01 VA Class: GA309 Chemical Name: 11α,13E)-(±)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic acid methyl ester Molecular Formula: C Treatment to reduce the risk of NSAIA-induced gastric ulcers in patients at high risk (e.g., concomitant debilitating disease, geriatric patients, history of upper GI ulcer) of developing complications (e.g., bleeding, perforation, death) from these ulcers. (See Pregnancy under Cautions.) Treatment to improve cervical inducibility (cervical “ripening”) in appropriately selected pregnant women with unfavorable cervices with a medical or obstetric need for labor induction†. A review of the therapeutic efficacy of misoprostol, a prostaglandin E analogue. (See Pregnancy and also see Lactation under Cautions.) If inadvertently administered during pregnancy or if the patient becomes pregnant while receiving the drug, discontinue therapy and inform patient of the potential hazard to the fetus. Intravaginal use may result in uterine hyperstimulation, uterine tetany, uterine rupture, amniotic fluid embolism, pelvic pain, retained placenta, severe genital bleeding, shock, fetal bradycardia, and fetal and maternal death, especially with dosages (See Interactions.) Chest pain, edema, diaphoresis, hypotension, hypertension, arrhythmia, phlebitis, increased serum concentrations of cardiac enzymes, syncope, MI (some fatal), and thromboembolic events (e.g., pulmonary embolism, arterial thrombosis, cerebrovascular accident) reported; causal relationship to drug not established. When used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents. (See Fetal/Neonatal Morbidity and Mortality and also see Contraindications under Cautions.) Ruptured ectopic pregnancy (rarely resulting in fatal hemorrhage); serious, rarely fatal, bacterial (e.g., Clostridium sordellii) infection and sepsis; or MI reported in a limited number of patients receiving intravaginal misoprostol with mifepristone for termination of pregnancy; causal relationship to regimen not established. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Misoprostol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Cytotec is indicated for the healing of duodenal ulcer and gastric ulcer including those induced by nonsteroidal anti-inflammatory drugs (NSAID) in arthritic patients at risk, whilst continuing their NSAID therapy. In addition, Cytotec can be used for the prophylaxis of NSAID-induced ulcers. Adults Healing of duodenal ulcer, gastric ulcer and NSAID-induced peptic ulcer: 800 micrograms daily in two or four divided doses taken with breakfast and / or each main meal and at bedtime. Treatment should be given initially for at least 4 weeks even if symptomatic relief has been achieved sooner. In most patients ulcers will be healed in 4 weeks but treatment may be continued for up to 8 weeks if required. If the ulcer relapses further treatment courses may be given. Prophylaxis of NSAID-induced peptic ulcer: 200 micrograms twice daily, three times daily or four times daily. Dosage should be individualised according to the clinical condition of each patient. 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Promo Codes Cytotec Pregnancy Dose. Direktmarketing; Ausstellungen/Messen; PR-Internet; Online Shop Beratung; Online. References a WHO Clinical practice handbook for safe abortion, 2014. b v on Hertzen et al. Lancet, 2007; Sheldon et al. 2016 FIAPAC abstract. Caguas, PR. FRONT BACK. BASE GLUED PAGE. PAGE 13. PAGE 2. PAGE 3. PAGE 12. PAGE 11. PAGE 4. Nota El texto español sigue al texto inglés. Cytotec.