Prednisone complications

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    Prednisone complications


    Prednisone is an anti-inflammatory drug that is classified as a glucocorticosteroid - a class of endogenous hormones that are produced by the adrenal gland in the human body. Glucocorticosteroids (or glucocorticoids) are stress hormones that aim to prepare the body to respond to infections, diseases and other stressful events like surgery, accidents and even pain caused by the withdrawal of certain medications etc. Prednisone is a synthetic form of glucocorticoid that is mainly prescribed for therapeutic reasons to minimize the intensity of inflammatory or autoimmune reactions in the body and is not generally considered a drug of abuse. However, surprisingly, abrupt cessation of therapy is associated with moderate to severe withdrawal symptoms. The intensity or severity of symptoms is dependent on the duration of therapy, underlying medical conditions and dosage frequency of prednisone. Withdrawal symptoms can include: In some susceptible patients, abrupt prednisone withdrawal may also lead to severe complications like acute adrenal crisis, which is a life-threatening condition that is marked by high grade fever, excessive sweating, changes in the complexion of skin, low blood pressure, dehydration, abdominal pain, flank pain, joint pain, changes in heart rate, rigors and shaking chills - ultimately culminating in confusion, delirium and coma or even death. The human body is very sensitive and calculated when it comes to the maintenance of its internal environment, so in situations where we consume glucocorticoids from external sources (like prednisone), the human adrenal glands shut down the production of glucocorticoids. Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines. Prednisone is also sometimes used to treat the symptoms of certain types of cancer. Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works.

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    Sep 16, 2015. If we observe what happens to patients taking high doses of prednisone, there is no doubt this drug can cause a wide variety of side-effects. Prednisone is a steroid used to treat inflammatory bowel disease IBD and other conditions. Here you'll find a list of prednisone side effects. Long-term use of prednisolone is associated with certain complications, including reduced resistance to infection, glaucoma, cataracts, delayed growth

    Prednisone is an inexpensive and effective type of corticosteroid medication that is frequently used in treating a flare-up in patients with inflammatory bowel disease (IBD). While this drug is often one that acts quickly, the side effects of prednisone are well-known for being troublesome to patients. Some of the most frequently discussed side effects are weight gain, insomnia, moodiness, hair growth, and acne. Prednisone is similar to a compound that is made naturally in the body's adrenal gland, and may also be used to treat a variety of inflammatory conditions. Because of the potential for serious and ongoing prednisone side effects, whenever possible, this drug should only be used on a short-term basis. Prednisone also suppresses the immune system, which may be necessary to dampen down inflammation from an autoimmune or immune-mediated disease. However, having a depressed immune system may also leave a patient open to developing other infections. Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, giant-cell arteritis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly. It can also cause depression or depressive symptoms and anxiety in some individuals.

    Prednisone complications

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    Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic. Apr 18, 2017. The US Food and Drug Administration require drug makers to list the possible side effects of prednisone and other corticosteroids, but the rate. May 17, 2017. Prednisone suppress the immune system and inflammation. Common side effects are weight gain, water retention, hypertension, headache.

     
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