Sertraline for depression

Discussion in 'Board Of Pharmacy' started by Colibrik, 28-Aug-2019.

  1. Volex XenForo Moderator

    Sertraline for depression


    Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Zoloft (generic name: sertraline) is part of a large family of antidepressants known as SSRI’s (selective serotonin reuptake inhibitors) which increase serotonin in the brain. Zoloft and Anxiety Depression and Pain Depression and Anxiety Zoloft and Prozac Depression and Worried Zoloft and Paxil Depression and Tiredness Zoloft and Lexapro Depression and Anger Zoloft and Wellbutrin Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. It is used for many different conditions such as depression, anxiety disorders and obsessive compulsive disorder. My intestines began to feel like they were burning. I could barely eat anything and felt nauseated all the time. Some of the symptoms have decreased but none have gone away. It did nothing to change the symptoms I was using it for. Treato does not provide medical advice, diagnosis or treatment. Zoloft is similar to the other SSRI’s with side effects such as dry mouth, insomnia or fatigue, and nausea and vomiting. Usage of the website does not substitute professional medical advice. I am completely burnt in places I have never been burnt like this before. I could not sit in the sun without burning straight away, this was with factor 50 and factor 30 suncream. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies.

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    Sertraline is not approved for use in children except for those with OCD. Depression. It is unclear if sertraline is any different than another SSRI, paroxetine, for depression. Evidence does not show a benefit in children with depression. With depression in dementia, there is no benefit compared to either placebo or mirtazapine. It is used to treat depression, panic disorder, and obsessive-compulsive disorder OCD. Sertraline works by affecting the balance of chemicals in the brain. Nov 25, 2018. Zoloft is a medication known as a selective serotonin reuptake inhibitor used to treat depression and other mental health conditions.

    Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. For some people with mild depression, antidepressants seem to have little effect. However, for people with more severe depression, antidepressants often make a big difference. Although antidepressants generally aren't as effective for mild depression, that doesn't mean that they never help. Depression affects each person differently, and each person responds to medications differently. Finding the right medication may take some trial and error. If an antidepressant seems to ease your symptoms, it may be a good treatment choice for you. If you're taking an antidepressant, don't stop taking it without talking to your doctor.

    Sertraline for depression

    Zoloft for treating Depression Treato, Sertraline - Uses, Side Effects, Interactions -

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  7. Sertraline helps many people recover from depression, and it has fewer unwanted effects than older antidepressants. Sertraline comes as tablets which are.

    • Sertraline an antidepressant - NHS. UK.
    • Zoloft sertraline hydrochloride for Depression -.
    • Side Effects of Zoloft Sertraline - Verywell Mind.

    Antidepressants are medications used to treat depression. There are a variety of medications that can be used to treat depression. These antidepressants all work to take away or reduce the. Prozac and Zoloft are drugs used to treat depression and other conditions. while the generic version of Zoloft is sertraline hydrochloride. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.

     
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    As a severe prednisone dependent asthmatic, I am all too familiar with the roller coaster that comes with prednisone tapering. Let’s start at the beginning prednisone is a steroid anti-inflammatory drug that has many uses in many diseases. It is prescribed in asthma to treat underlining inflammation which is an underlying driver of asthma. I am one of those asthmatics that has a significant inflammation component, steroids are a large component of my treatment. I was definitely not excited to become prednisone dependent but I have tried everything and I was out of options that controlled my inflammation the way that prednisone does. I have gone through many bursts for exacerbation or even periods of being on higher doses for some time. It is important to note that every asthmatic is different and may have different experiences with prednisone use tapering. Adrenal Insufficiency Primary & Secondary Causes and Treatment Reducing Steroids while on a Low Dose & Activating the Adrenal Glands. Acute adrenal crisis MedlinePlus Medical Encyclopedia
     
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